Association between vitamin D deficiency and tuberculosis in a Korean population
METHOD: This was an age- and sex-matched case-control analysis of 94 TB cohort and 282 Korean national survey participants.
RESULTS: The median baseline 25-hydroxyvitamin D (25[OH]D) level in the TB group (9.86 ng/ml, IQR 7.19–14.15) was lower than in controls (16.03 ng/ml, IQR 12.38–20.30, P < 0.001). The prevalence of severe vitamin D deficiency was higher in patients with TB (51.1%) than in controls (8.2%, P = 0.001). The median 25(OH)D level increased from 11.40 ng/ml (IQR 7.85–15.73) to 13.18 ng/ml (IQR 10.60–19.71) after treatment completion (P = 0.037). On multivariate analysis, presence of TB and history of TB were independently associated with severe vitamin D deficiency.
CONCLUSION: Patients with TB had a higher prevalence of vitamin D deficiency than control subjects in a Korean population. The median 25(OH)D level increased after TB treatment. Further studies are needed to establish a causal relationship.
Keywords: TB; vitamin D deficiency
Document Type: Research Article
Affiliations: Division of Pulmonology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea
Publication date: 01 January 2014
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