Risk factors and timing of default from treatment for non-multidrug-resistant tuberculosis in Moldova
OBJECTIVE: To assess risk factors and timing of default from treatment for non-MDR-TB from 2007 to 2010.
DESIGN: A retrospective analysis of routine surveillance data on all non-MDR-TB patients reported.
RESULTS: A total of 14.7% of non-MDR-TB patients defaulted from treatment during the study period. Independent risk factors for default included sociodemographic factors, such as homelessness, living alone, less formal education and spending substantial time outside Moldova in the year prior to diagnosis; and health-related factors such as human immunodeficiency virus co-infection, greater lung pathology and increasing TB drug resistance. Anti-tuberculosis treatment is usually initiated within an institutional setting in Moldova, and the default risk was highest in the month following the phase of hospitalized treatment (among civilians) and after leaving prison (among those diagnosed while incarcerated).
CONCLUSIONS: Targeted interventions to increase treatment adherence for patients at highest risk of default, and improving the continuity of care for patients transitioning from institutional to community care may substantially reduce risk of default.
Document Type: Research Article
Affiliations: 1: Brigham and Women's Hospital, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA 2: National Centre of Health Management, Chisinau, Republic of Moldova 3: Center for Health Policies and Studies, Chisinau, Republic of Moldova 4: Brigham and Women's Hospital, Boston, Massachusetts, USA; Harvard School of Public Health, Boston, Massachusetts, USA
Publication date: March 1, 2013
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