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Home / The International Journal of Tuberculosis and Lung Disease, Volume 16, Number 7

Molecular analysis of isoniazid-resistant Mycobacterium tuberculosis isolates in Uruguay [Short communication]

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The incidence of tuberculosis (TB) is increasing in high-risk populations in Uruguay, possibly owing to emerging resistance. Mycobacterial interspersed repetitive units (MIRU) genotyping and katG sequence analysis of isoniazid (INH) resistance-associated mutations were performed in 45 INH-resistant Mycobacterium tuberculosis isolates in Uruguayan patients. The genotype distribution among INH-resistant isolates shares features of that of neighbouring countries, with a predominance of Latin American and Mediterranean, T and Haarlem genotypes, although the S genotype was particularly frequent among our isolates. Forty-four per cent of INH-resistant strains harboured the S315T mutation in katG; we found novel katG mutations (W321X, G269T, P232R and G221Wfs1) that could explain INH resistance.

Keywords: drug resistance; epidemiology; genotyping

Document Type: Research Article

Affiliations: 1: Unidad de Biología Molecular, Institut Pasteur de Montevideo, Montevideo, Uruguay 2: Departamento de Laboratorio, Comisión Honoraria de Lucha Anti-Tuberculosis y Enfermedades Prevalentes, Montevideo, Uruguay 3: Department of Clinical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands 4: Unidad de Biología Molecular, Institut Pasteur de Montevideo, Montevideo, Uruguay; Departamento de Bioquímica, Facultad de Medicina, Montevideo, Uruguay

Publication date: 01 July 2012

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