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Free Content Study of KIR genes in Lebanese patients with tuberculosis

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A total of 103 Lebanese tuberculosis (TB) cases and 38 controls without TB were studied for the killer cell i mmunoglobulin-like receptors (KIR) genotypic profile using polymerase chain reaction sequence-specific primers. Patients and controls were assigned to the AA, AB or BB genotypes based on their A or B haplotype genetic make-up, and KIR gene frequencies were compared. We found an increase in the KIR A haplotype in TB patients compared to controls, and only KIR 2DL3 was found to be significantly more prevalent among TB patients. This confirms the findings of another unique international study performed in the Mexican population showing a greater repertoire of inhibitory KIR genes among TB patients than controls.
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Keywords: GENOTYPING; KIR; LEBANESE; TUBERCULOSIS

Document Type: Short Communication

Affiliations: 1: Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon 2: National Tuberculosis Center, Beirut, Lebanon 3: Rosalind Franklin University, Department of Internal Medicine, North Chicago, Illinois, USA

Publication date: December 1, 2011

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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