Adherence to isoniazid preventive therapy in children exposed to tuberculosis: a prospective study from Guinea-Bissau
METHODS: Children were enrolled on IPT if they were aged ≤5 years or 5–15 years and presented a tuberculin skin test induration of ≥10 mm. Children were included from the demographic surveillance system of the Bandim Health Project in Bissau, Guinea-Bissau. The main outcome measures were adherence, completion rates and side effects during 9 months of IPT. The main outcome was 6 consecutive months of at least 80% adherence.
RESULTS: A total of 2631 children were identified as contacts of adult TB cases. Among the children identi- fied, 1895 (72%) were evaluated for eligibility for IPT, and 820 were enrolled in the study: 609 were aged ≤5 years and 211 aged 5–15 years. A total of 79% of the prescribed doses were taken, with 65% of the children taking > 80% of their doses. In all, 51% completed more than 6 consecutive months of IPT.
CONCLUSION: Overall adherence to IPT was better than previously reported from TB-endemic areas, with 76% of the children completing at least 6 months of treatment, with more than 80% adherence.
Document Type: Research Article
Affiliations: 1: Bandim Health Project, Indepth Network, Bissau, Guinea-Bissau 2: Bandim Health Project, Indepth Network, Bissau, Guinea-Bissau; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark 3: National Tuberculosis Referral Hospital (Hospital de Pneumologia Raoul Follereau), Bissau 4: Hospital Nacional Simao Mendes, Bissau, Guinea-Bissau 5: Infectious Diseases Research Group, Department of Clinical Sciences, Lund University, Malmö, Sweden
Publication date: December 1, 2011
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