Indeterminate QuantiFERON® -TB Gold results in a public health clinic setting
DESIGN: Retrospective cross-sectional multivariate logistic regression analyses of patients receiving QFT-G from October 2006 to June 2008. Analyses were performed separately depending on whether the indeterminate result was due to positive (low mitogen) or negative (high nil) control failure.
RESULTS: Of 28 864 individuals tested, 2058 (7%) tested positive, 26 284 (91%) negative, and 522 (2%) were indeterminate (low mitogen, n = 264; high nil, n = 258). Low mitogen results were more frequent among those aged < 10 years (ORadj 3.7, 95%CI 2.4–5.9), females (ORadj 1.4, 95%CI 1.1–1.8), Asians (ORadj 2.1, 95%CI 1.3–3.4) and the US-born (ORadj 1.9, 95%CI 1.4–2.6) and less frequent among Hispanics (ORadj 0.6, 95%CI 0.4–1.0). High nil results were more frequent among Hispanics (ORadj 1.7, 95%CI 1.0–2.8) and less frequent among the US-born (ORadj 0.6, 95%CI 0.5– 0.8). Among patients who received a repeat QFT-G (n = 137), 4% tested positive, 64% negative and 32% had a second indeterminate result, always of the same type.
CONCLUSION: Age, race/ethnicity and sex were associ- ated with indeterminate QFT-G results. Most follow-up tests were negative, although a modest proportion were repeatedly indeterminate. Further studies evaluating the mechanisms of QFT-G indeterminate results are needed.
Document Type: Research Article
Affiliations: 1: Division of Infectious Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA; New York City Department of Health and Mental Hygiene, New York, New York, USA 2: New York City Department of Health and Mental Hygiene, New York, New York, USA
Publication date: December 1, 2011
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