Programmatic impact of using QuantiFERON® -TB Gold in routine contact investigation activities
METHODS: Contacts of culture-confirmed pulmonary TB cases reported to the San Francisco Department of Public Health between 1 March 2005 and 31 December 2007 were included.
RESULTS: Of 1291 contacts meeting the eligibility criteria, 641 (50%) were tested with QFT-G and 650 (50%) with TST. Contacts tested with QFT-G were more likely to complete evaluation (64% vs. 56%, ORadj = 1.52, 95%CI 1.12–2.06). Infected contacts started (89% vs. 72%, ORadj = 5.18, 95%CI 2.10–14.18) and completed (70% vs. 53%, ORadj = 3.37, 95%CI 1.78–6.56) LTBI treatment more often in the group tested with QFT-G. Positive QFT-G results, but not positive TST results, correlated with the intensity, proximity and duration of TB exposure in foreign-born subjects.
CONCLUSION: More contacts were successfully evaluated and treated for LTBI when screened with QFT-G compared to TST. Measures of exposure correlated better with QFT-G-positive results and, therefore, appropriately identified high-risk contacts for TB prevention.
Document Type: Research Article
Affiliations: 1: Tuberculosis Control Section, San Francisco Department of Public Health, San Francisco, California, USA 2: Tuberculosis Control Section, San Francisco Department of Public Health, San Francisco, California; Division of TB Elimination, Field Services Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Publication date: December 1, 2011
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