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Free Content SLC11A1 and VDR gene variants and susceptibility to tuberculosis and disease progression in East India

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SETTING: Despite efforts at disease control, the inci- dence of tuberculosis (TB) remains high in India. OBJECTIVE: To assess the role of VDR and SLC11A1 gene polymorphisms in the development of pulmonary TB (PTB) in an ethnically matched population of India. DESIGN: In this case-control study, five variants (INT4/ rs3731865, 823C/T/rs17221959, D543N/rs17235409, 577G/A/rs1059823 and TGTG deletion-3UTR/rs172 35416) of SLC11A1 and three (BsmI/rs1544410, FokI/ rs10735810 and TaqI/rs731236) of the VDR gene were studied in 101 TB patients and 225 controls from Kolkata, India. RESULTS: Statistically significant associations were ob- served for INT4: GC (OR 4.54 95%CI 2.38–8.68), CC (OR 35.20, 95%CI 9.15–135.38), 3 UTR (TGTG+ /–, OR 2.96, 95%CI 1.52–5.78), TGTG– /– (OR 3.52, 95%CI 1.62–7.61) and 823C/T (CT, OR 0.31, 95%CI 0.17–0.58) variants of the SLC11A1 gene. Significantly different genotype frequencies between different groups of patients elucidated the role of the INT4 (P = 0.031), 577G/A (P = 0.033) and FokI (P = 0.02) variants in disease progression and the development of cavitary disease. Five haplotypes were also identified as having a significant association with PTB. CONCLUSION: This study, the first to include evidence on 577G/A and INT4, reports a significant association between SLC11A1 gene variants and PTB with respect to susceptibility and subsequent disease progression in East India.
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Keywords: CASE CONTROL; PULMONARY TUBERCULOSIS; SLC11A1; SUSCEPTIBILITY; VDR

Document Type: Research Article

Affiliations: 1: National DNA Analysis Center, Central Forensic Science Laboratory, Kolkata, India; The Sol Sherry Thrombosis Research Center, Philadelphia, Pennsylvania, USA; Biostatistics Consulting Center, Temple University School of Medicine, Philadelphia, Pennsylvania, USA 2: Directorate of Forensic Science, MHA, Government of India, New Delhi, India 3: National DNA Analysis Center, Central Forensic Science Laboratory, Kolkata, India

Publication date: November 1, 2011

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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