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Home / The International Journal of Tuberculosis and Lung Disease, Volume 14, Number 10

South Carolina tuberculosis genotype cluster investigation: a tale of substance abuse and recurrent disease [Notes from the field]

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The South Carolina Tuberculosis (TB) Control Division ranked all the TB genotype clusters (two or more cases with matching genotypes) in the state based on the number of cases. The largest cluster, PCR00002, was investigated to determine if the cluster represented recent Mycobacterium tuberculosis transmission, and if so, to identify associated risk factors. The PCR0002 cluster, which included pediatric cases, clearly represented recent M. tuberculosis transmission. The two primary factors contributing to cluster growth were substance abuse and recurrent TB disease. Elimination of ongoing M. tuberculosis transmission in this population will require concurrent treatment for TB disease and substance abuse.

Keywords: contact tracing; epidemiology; genotype; substance abuse; tuberculosis

Document Type: Short Communication

Affiliations: 1: Division of Tuberculosis Elimination, National Center for HIV/AIDS, Viral Hepatitis, STD, and Tuberculosis Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA 2: Tuberculosis Control Division, South Carolina Department of Health and Environmental Control, Columbia, South Carolina, USA 3: Department of Internal Medicine, Emory University School of Medicine, Atlanta, Georgia, USA 4: York County Health Department, Rock Hill, South Carolina, USA

Publication date: 01 October 2010

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