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Free Content Predictors of mortality in tuberculous meningitis: a multivariate analysis of 160 cases

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OBJECTIVE: To evaluate predictors of mortality in 160 patients with tuberculous meningitis (TBM).

DESIGN: One hundred and sixty patients with TBM who had been followed for 11 years in a tertiary referral centre hospital were assessed retrospectively. Features considered as predictors of mortality in TBM were studied by multivariate logistic regression to develop a prognostic rule.

RESULTS: Of 160 patients, 84% were in Stages II and III; 27 (17%) died. In univariate analysis, age, stage, altered sensorium, underlying comorbidities, pulmonary tuberculosis, leukocytosis and cerebrospinal fluid (CSF)/blood glucose < 0.30 and rise in CSF protein were associated with an increased risk of death. In multivariable analysis, age (OR 4.64, 95%CI 1.03–24.74, P = 0.046), altered sensorium (OR 8.62, 95%CI 1.25–110.0, P = 0.036), underlying comorbidity (OR 9.75, 95%CI 1.58–59.95, P = 0.014) and leukocytosis (OR 9.74, 95%CI 1.67–56.7, P = 0.011) were shown to be the best predictors of mortality in TBM.

CONCLUSIONS: We observed that TBM patients who died were more likely to be older and have altered mental status on admission, underlying comorbidities and leukocytosis than TBM patients who survived. These factors were the most important predictors of mortality from TBM.
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Keywords: Mycobacterium tuberculosis; death; meningitis; predictor; tuberculosis

Document Type: Regular Paper

Affiliations: Department of Infectious Diseases and Clinical Microbiology, Haseki Training and Research Hospital, Istanbul, Turkey

Publication date: 01 October 2010

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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