Skip to main content
padlock icon - secure page this page is secure

Free Content Use of the QuantiFERON®-TB Gold test to confirm latent tuberculosis infection in a Canadian tuberculosis clinic

Download Article:
(PDF 251.9 kb)
SETTING: Capital Health Tuberculosis (TB) Clinic, Edmonton, Alberta, Canada.

OBJECTIVE: To analyze the QuantiFERON®-TB Gold In-Tube test (QFT) results after implementation as a routine test for tuberculin skin test (TST) positive patients.

DESIGN: From November 2004 until January 2007, patients who were TST-positive and were eligible for preventive treatment based on Canadian guidelines, were offered a QFT.

RESULTS: Of 1446 TST-positive patients, only 566 (39.6%) were QFT-positive. Categorized by reason for TST testing, 43.1% of 304 contacts, 32.8% of 348 employment screens and 24.2% of 298 post secondary school screens were QFT-positive. In contrast, 59.7% of 290 immigration screens were QFT-positive. A multivariate analysis found that QFT positivity was associated with older age, larger TST size, high-incidence TB region of birth, history of TB and chest X-ray findings suggestive of previous TB.

CONCLUSION: Implementation of the QFT as a secondary test for latent TB infection (LTBI) can significantly reduce the number of patients given LTBI treatment in a low-incidence country such as Canada.
No Reference information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics

Keywords: cost; diagnosis; interferon; tuberculin; tuberculosis

Document Type: Regular Paper

Affiliations: 1: Department of Medicine, University of Alberta, Edmonton, Alberta, Canada 2: Capital Health TB Clinics, University of Alberta, Edmonton, Alberta, Canada 3: Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada

Publication date: June 1, 2009

More about this publication?
  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on lung health world-wide.

    To share scientific research of immediate concern as rapidly as possible, The Union is fast-tracking the publication of certain articles from the IJTLD and publishing them on The Union website, prior to their publication in the Journal. Read fast-track articles.

    Certain IJTLD articles are also selected for translation into French, Spanish, Chinese or Russian. These are available on the Union website.

  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • International Journal of Tuberculosis and Lung Disease
  • Public Health Action
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more