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Free Content Factors contributing to treatment success among tuberculosis patients: a prospective cohort study in Bangkok

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SETTING: Chest Clinic, Ministry of Public Health and health care centres, Bangkok Metropolitan Administration.

OBJECTIVE: To determine patient factors predicting successful tuberculosis (TB) treatment.

DESIGN: A prospective cohort was conducted during May 2004 to November 2005. Newly diagnosed TB patients aged ≥15 years were recruited after giving informed consent. Three sets of questionnaires were used to collect data from the patients three times. Data were also gathered from treatment cards.

RESULTS: Of 1241 patients, 81.1% were successfully treated. Bivariate analysis indicated that patients' sex, education, occupation, level of knowledge about TB and adverse effects were associated with treatment success. Unconditional logistic regression analysis showed that females had a higher success rate than males (OR = 1.9, 95%CI 1.2–2.9). Patients with regular incomes had twice the likelihood of success of the unemployed (OR = 2.0, 95%CI 1.1–3.5). Patients with high knowledge levels were more likely to complete treatment (OR = 2.0, 95%CI 1.2–3.4), while those with adverse effects were less likely to adhere (OR = 0.6, 95%CI 0.4–0.9).

CONCLUSION: The current low treatment success rate may be partly due to inadequate knowledge about TB among patients. Improvements in health education and early detection and management of adverse effects should be prioritised by the National Tuberculosis Programme.
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Keywords: TB patient; prospective cohort; treatment success

Document Type: Regular Paper

Affiliations: 1: Department of Social and Environmental Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand 2: Department of Social and Environmental Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; and Clinical Research Centre, Bumrungrad International Hospital, Bangkok, Thailand 3: Bureau of HIV/AIDS, TB and STIs, Department of Disease Control, Ministry of Public Health, Bangkok, Thailand

Publication date: October 1, 2008

More about this publication?
  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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