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Free Content Programmatic implementation of rapid DST for Mycobacterium tuberculosisin Peru

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BACKGROUND: Performance characteristics of novel rapid drug susceptibility tests (DST) for Mycobacterium tuberculosis may change when moving from research to implementation in actual public health practice. We describe the performance characteristics of a direct, rapid DST when implemented in Lima, Peru.

METHODS: A district laboratory validated conventional proportions and nitrate reductase methods. We collected data on samples submitted for DST from January 2005 to June 2007 and calculated frequency of testing and results, and median time to test results.

RESULTS: A total of 4102 DSTs were performed by conventional DST and 895 by nitrate reductase. Results were obtained from 72.8% of samples by conventional DST and from 70.2% of those processed by Griess; respectively 26.4% and 31.5% were multidrug-resistant tuberculosis. The median time from sample collection to test result was 31 days for Griess vs. 99 days for conventional DST.

CONCLUSIONS: Preliminary experience with the Griess method demonstrates favorable performance under program conditions.
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Keywords: DST; laboratories; multidrug-resistant; resource-poor settings; tuberculosis

Document Type: Regular Paper

Affiliations: 1: Instituto Nacional de Salud, Lima, Peru 2: Dirección de Salud V Lima Ciudad, Programa de Control de Tuberculosis, Lima, Peru 3: Centers for Disease Control and Prevention, Atlanta, Georgia, USA 4: Partners In Health, Boston, Massachusetts, USA 5: Socios En Salud, Lima, Peru 6: Partners In Health, Boston, Massachusetts, USA; Socios En Salud, Lima, Peru; and Division of Social Medicine and Health Inequalities, Brigham and Women's Hospital, Boston, Massachusetts, USA 7: Peruvian National Tuberculosis Program, Lima, Peru

Publication date: July 1, 2008

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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