Molecular epidemiology of Mycobacterium tuberculosis in an urban area in Japan, 2002–2006
OBJECTIVE: To evaluate the status of transmission of Mycobacterium tuberculosis in Shinjuku City to allocate resources efficiently and effectively for a successful tuberculosis (TB) control programme.
DESIGN: Observational descriptive study combining the genotype data of M. tuberculosis with TB patient profiles.
RESULTS: The genotype clustering rate was significantly higher in males (adjusted odds ratio [aOR] 1.94, 95%CI 1.04–3.65, P = 0.038), patients aged <40 years (aOR 2.09, 95%CI 1.17–3.71, P = 0.012) and the homeless (aOR 2.72, 95%CI 1.42–5.20, P = 0.002), and was lower for the foreign-born (aOR 0.21, 95%CI 0.06–0.76, P = 0.017). Among 45 genotype clusters containing 152 TB patients, 26 clusters containing 102 patients (67.1%) were composed of a mix of homeless and non-homeless patients. One of the mixed clusters included an 8-month-old infant born in Japan.
CONCLUSION: The study revealed that M. tuberculosis transmission occurred more frequently among the homeless than in non-homeless persons. However, transmission by casual contact between the homeless and the general population was also shown to occur.
Document Type: Regular Paper
Affiliations: 1: Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose, Japan 2: Shinjuku Public Health Centre, Shinjuku, Japan 3: Nishi-Shinjuku Health Centre, Shinjuku, Japan 4: Tokyo Metropolitan Institute of Health, Shinjuku, Japan 5: National Institute of Infectious Diseases, Leprosy Research Centre, Higashimurayama, Japan
Publication date: May 1, 2008
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