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Home / The International Journal of Tuberculosis and Lung Disease, Volume 6, Number 6

Transforming growth factor-beta gene polymorphism in sarcoidosis and tuberculosis patients

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SETTING: Transforming growth factor-beta (TGF-β) plays an important role in many diseases, influencing as it does such processes as immune responses, fibrosing processes, and angiogenesis. Recently, polymorphisms have been described for TGF-β that are associated with the risk of several diseases. In this study, we investigated whether TGF-β 1 polymorphism has an effect on sarcoidosis and tuberculosis.

OBJECTIVE: TGF-β 1 Codon 10 T869C polymorphism was investigated in 110 healthy control subjects, 104 sarcoidosis patients, and 101 tuberculosis patients.

DESIGN: The TGF-β genotype was determined using polymerase chain reaction restriction fragment length polymorphism.

RESULTS: We found no significant differences in TGF-β genotypes between sarcoidosis patients and healthy controls or tuberculosis patients and controls. The long axis of the tuberculin skin test was larger in the CC type compared with the CT type. However, there was no association between the TGF-β genotype and the roentgenographic stage, the disappearance of shadows, or organ involvement in sarcoidosis, nor any association between genotype, the extent or type of roentgenographic shadow, or detected volume of tubercle bacilli in tuberculosis.

CONCLUSION: From the results, we believe that TGF-β polymorphisms on the whole do not have a strong influence on disease onset or clinical progression in sarcoidosis and tuberculosis, although this polymorphism might have an effect on the immune response in a tuberculosis host.

Keywords: TGF-; gene; polymorphism; sarcoidosis, tuberculosis

Document Type: Regular Paper

Affiliations: 1: Second Department of Internal Medicine, Nagoya City University, Medical School, Nagoya, Japan 2: Department of Respiratory Disease, Nagoya Daini Red Cross Hospital, Nagoya, Japan 3: Department of Respiratory Disease, Daido Hospital, Nagoya, Japan 4: Second Department of Internal Medicine, Aichi Medical University, Medical School, Nagakute, Japan 5: Second Department of Pathology, Nagoya City University, Medical School, Nagoya, Japan

Publication date: 01 June 2002

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  • The International Journal of Tuberculosis and Lung Disease (IJTLD) is for clinical research and epidemiological studies on lung health, including articles on TB, TB-HIV and respiratory diseases such as COVID-19, asthma, COPD, child lung health and the hazards of tobacco and air pollution. Individuals and institutes can subscribe to the IJTLD online or in print – simply email us at [email protected] for details.

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