Treatment of ulcerative endobronchial tuberculosis and bronchial stenosis with aerosolized streptomycin and steroids
DESIGN: An observational, historical, controlled comparative study. Retrospective analysis of 27 patients treated with conventional therapy, and prospective analysis of 30 patients treated with aerosol therapy.
METHOD AND PATIENTS: Flexible bronchoscopy was performed at least twice in 57 patients with ulcerative EBTB, in whom the degree of bronchial stenosis between the first and last bronchoscopic examinations was estimated. Bronchial stenosis was graded as minimal, mild, moderate, severe or obstructive, and the follow-up of bronchial stenosis assessed as aggravation, no change or improvement.
RESULTS: Conventional therapies led to aggravation in 13 patients, no change in 13 patients, and improvement in one patient. Aerosol therapy led to no change in 27 patients, and improvement in three patients. No patients developed aggravation. The differences between the therapeutic groups were significant.
CONCLUSION: Aerosol therapy helps to prevent progressively severe bronchial stenosis due to EBTB.
Keywords: aerosol therapy; bronchial stenosis; corticosteroids; endobronchial tuberculosis; streptomycin
Document Type: Regular Paper
Affiliations: Internal Medicine, Kurume University School of Medicine, Kurume, Japan
Publication date: 01 August 2001
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