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Free Content Numbers of IFN-γ-producing cells against ESAT-6 increase in tuberculosis patients during chemotherapy [Technical Note]

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ESAT-6 is a specific Mycobacterium tuberculosis complex antigen and strong inducer of interferon-gamma (IFN-γ) production by T cells from tuberculosis patient T-cells. We studied the frequency of IFN-γ producing cells reacting to ESAT-6 during anti-tuberculosis chemotherapy. The numbers of IFN-γ producing cells in the peripheral blood were higher in tuberculosis patients after discharge from specific anti-tuberculosis chemotherapy, compared with untreated patients. These results indicate that monitoring specific M. tuberculosis antigen reactivity during anti-tuberculosis chemotherapy may avoid premature termination of treatment and resistant strains.
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Keywords: ESAT-6 antigen; M. tuberculosis infection; human IFN-γ; human T-cells; tuberculosis

Document Type: Short Communication

Affiliations: Max-Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany

Publication date: December 1, 2000

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on lung health world-wide.

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