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Free Content Numbers of IFN-γ-producing cells against ESAT-6 increase in tuberculosis patients during chemotherapy [Technical Note]

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ESAT-6 is a specific Mycobacterium tuberculosis complex antigen and strong inducer of interferon-gamma (IFN-γ) production by T cells from tuberculosis patient T-cells. We studied the frequency of IFN-γ producing cells reacting to ESAT-6 during anti-tuberculosis chemotherapy. The numbers of IFN-γ producing cells in the peripheral blood were higher in tuberculosis patients after discharge from specific anti-tuberculosis chemotherapy, compared with untreated patients. These results indicate that monitoring specific M. tuberculosis antigen reactivity during anti-tuberculosis chemotherapy may avoid premature termination of treatment and resistant strains.
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Keywords: ESAT-6 antigen; M. tuberculosis infection; human IFN-γ; human T-cells; tuberculosis

Document Type: Short Communication

Affiliations: Max-Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany

Publication date: December 1, 2000

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on lung health world-wide.

    To share scientific research of immediate concern as rapidly as possible, The Union is fast-tracking the publication of certain articles from the IJTLD and publishing them on The Union website, prior to their publication in the Journal. Read fast-track articles.

    Certain IJTLD articles are also selected for translation into French, Spanish, Chinese or Russian. These are available on the Union website.

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