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Home / The International Journal of Tuberculosis and Lung Disease, Volume 1, Number 3

Detection of rifampicin and isoniazid resistances of Mycobacterium tuberculosis strains by particle counting immunoassay (PACIA) [Technical Note]

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The particle agglutinated counting immunoassay (PACIA) was used to determine the susceptibility of Mycobacterium tuberculosis strains to the two major antimycobacterial drugs, isoniazid and rifampicin. On evaluating 12 M. tuberculosis strains with different sensitivities, our results were in complete accordance with those obtained using the well-known BACTEC system. The PACIA technique is automated and quite inexpensive. Interpretation of the test may be achieved in as little as five days.

Keywords: M. tuberculosis; drug susceptibility; latex agglutination

Document Type: Short Communication

Affiliations: 1: Laboratoire de Physiologie Cardio-Respiratoire et Service de Microbiologie, Hopital Erasme, Université Libre de Bruxelles, Belgium 2: Institute de Médecine Expérimentale, Université Catholique de Louvain 3: Pasteur Institute, Brussels, Belgium 4: Institute of Tropical Medicine, Antwerp, Belgium

Publication date: June 1, 1997

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