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Side-port Endoscopic Imaging System with Macroscopic and Microscopic Field of View

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Noninvasive diagnosis and treatment of disease, which can greatly reduce the pain of patients and improve the efficiency of diagnosis, is increasingly advocated in modern health care. Traditional endoscopy as an important clinical diagnostic tool can provide only rough information on the structure of the tissue. In order to obtain morphological information at the cellular level, biopsy is often required. However, biopsy brings suffering to the patient and is costly. In recent years, the confocal endoscopic imaging system has been developed, yet has not been widely applied owning to the small imaging field of view. In view of these problems, we designed an endoscopic microscopic imaging system based on the combination of macroscopic vision and microscopic resolution. Here, we describe the design principle of the system. We further demonstrate the feasibility of the system by performing automated cell counts in an in vivo subcutaneous cancer model.
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Document Type: Research Article

Publication date: November 1, 2018

This article was made available online on December 10, 2018 as a Fast Track article with title: "Side-port Endoscopic Imaging System with Macroscopic and Microscopic Field of View".

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  • The Journal of Imaging Science and Technology (JIST) is dedicated to the advancement of imaging science knowledge, the practical applications of such knowledge, and how imaging science relates to other fields of study. The pages of this journal are open to reports of new theoretical or experimental results, and to comprehensive reviews. Only original manuscripts that have not been previously published, nor currently submitted for publication elsewhere, should be submitted.

    IS&T's JIST-first publication option allows authors wishing to present their work at conferences, but have a journal citation for their paper, to submit a paper to JIST that follows the same rigorous peer-review vetting and publication process as traditional JIST articles, but with the benefit of a condensed time-to-publication time frame and guaranteed conference presentation slot.

    Please note: For purposes of its Digital Library content, IS&T defines Open Access as papers that will be downloadable in their entirety for free in perpetuity. Copyright restrictions on papers vary; see individual paper for details.

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