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Open Access Tubule Segmentation of Fluorescence Microscopy Images Based on Convolutional Neural Networks With Inhomogeneity Correction

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Fluorescence microscopy has become a widely used tool for studying various biological structures of in vivo tissue or cells. However, quantitative analysis of these biological structures remains a challenge due to their complexity which is exacerbated by distortions caused by lens aberrations and light scattering. Moreover, manual quantification of such image volumes is an intractable and error-prone process, making the need for automated image analysis methods crucial. This paper describes a segmentation method for tubular structures in fluorescence microscopy images using convolutional neural networks with data augmentation and inhomogeneity correction. The segmentation results of the proposed method are visually and numerically compared with other microscopy segmentation methods. Experimental results indicate that the proposed method has better performance with correctly segmenting and identifying multiple tubular structures compared to other methods.
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Document Type: Research Article

Publication date: January 1, 2018

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  • For more than 30 years, the Electronic Imaging Symposium has been serving those in the broad community - from academia and industry - who work on imaging science and digital technologies. The breadth of the Symposium covers the entire imaging science ecosystem, from capture (sensors, camera) through image processing (image quality, color and appearance) to how we and our surrogate machines see and interpret images. Applications covered include augmented reality, autonomous vehicles, machine vision, data analysis, digital and mobile photography, security, virtual reality, and human vision. IS&T began sole sponsorship of the meeting in 2016. All papers presented at EIs 20+ conferences are open access.

    Please note: For purposes of its Digital Library content, IS&T defines Open Access as papers that will be downloadable in their entirety for free in perpetuity. Copyright restrictions on papers vary; see individual paper for details.

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