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Free Content Implantation of Natural Hydroxyapatite from Porcine Bone into Soft Tissues in Mice

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The natural origin of hydroxyapatite (HA) derived from pig bones (Polish patent No.P-359 960 pending from 5th May 2003) was histologically examined for its biocompatibility following implantation into mouse muscles. The implanted ceramic was encapsulated by well vascularized connective tissue and very slowly resorbed by multinucleated cells. This material did not elicit an immune reaction and adjacent bones were unaffected. This ceramic could be safely used as a filling material alone, or as a composite graft.

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Document Type: Research Article

Publication date: 2005

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  • Folia biologica is an international quarterly journal that publishes papers on the broad field of experimental zoology, nuclear and chromosome research, and also ultrastructural studies. All papers are subject to peer reviews. Indexed in: ISI Master Journal List, Current Contents, Polish Scientific Journals Contents. I.F. 0.667
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