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NSAR in the light of fever, inflammation and pain NSAR im Lichte von Fieber, Entzündung und Schmerz

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Among the prostanoids especially Prostaglandin E2(PGE2) is a key player in the genesis of fever, inflammation and inflammatory pain as it is increasingly synthesized by the inducible Cyclooxygenase-2 (COX-2). Inhibiting COX enzymes decreases PGE2 synthesis which results in reduction of fever and improves inflammatory and painful states in diseases as rheumatoid arthritis.

German
Bei der Genese von Fieber, Entzündung und entzündlichem Schmerz spielt unter den Prostanoiden vor allem das Prostaglandin E2 (PGE2) eine wichtige Rolle, das durch die induzierbare Cyclooxygenase-2 (COX-2) verstärkt gebildet wird. COX-Hemmung mindert die PGE2-Synthese, erzeugt somit eine Fiebersenkung und bessert Schmerz und entzündliche Prozesse bei Erkrankungen wie Rheumatoider Arthritis.
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Language: German

Document Type: Research Article

Publication date: 01 January 2017

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