Skip to main content
padlock icon - secure page this page is secure

Open Access Preservative system development for argan oil-loaded nanostructured lipid carriers

Download Article:
(PDF 1,549 kb)
Nanostructured lipid carriers (NLC) are used in many dermal cosmetic formulations. To prevent microbiological spoilage of NLC suspensions preservative systems must be used. Preservatives can impair the physical stability of NLC suspensions. Therefore, a systematic screening of preservative systems should be performed and the compatibility of these preservative systems with each NLC formulation has to be investigated. In this study three Argan oil-loaded NLC formulations were developed. Ethanol, propylene glycol and pentylene glycol were admixed to these formulations as preservative systems. The physical stability of the non-preserved and preserved formulations has been investigated. Upon admixing 20% w/w ethanol to the selected formulations, immediate particle aggregation could be detected using laser diffractometry and after 24 hours gelling occurred. This was accompanied with a lowering of Zeta potential value. Samples preserved with 10% w/w propylene glycol did not show any change in particle size or in Zeta potential, in comparison to the non-preserved formulation, when measured after one day and 120 days. Samples preserved with 5% pentylene glycol proved also to be stable after 120 days and did not show any change in particle size or Zeta potential.
No References for this article.
No Supplementary Data.
No Article Media
No Metrics

Document Type: Research Article

Publication date: 01 March 2011

More about this publication?
  • Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
  • Information for Authors
  • Submit a Paper
  • Subscribe to this Title
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more