Sialidases in biological systems
Sialidases are very common in biological systems. They are found particularly in diverse virus families and bacteria, but also in protozoa, some invertebrates and mammalian. The enzymes differ in their biochemical properties, e.g., kinetics, binding affinity or substrate preference. Nevertheless, they have conserved domains and structural similarities. Their functions offer a wide spread spectrum in nutrition, pathomechanisms and communication in mammalian. In pathogen organisms sialidases give insight in coevolution and interaction between pathogen or commensale and host. As well the enzymes are of interest in drug targeting, like neuraminidase inhibitors of influenza viruses.
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Document Type: Review Article
Publication date: August 1, 2010
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- Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
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