Histamine interaction with Zn2+ and Cu2+ porphyrins
Histamine may be present in biological fluids and in pharmaceutical dosage forms such as antiallergenic agents; when in excess, it causes a disorder called histaminosis. Many techniques have been developed to determine the concentration of this compound but the application of such methods
is complicated and laborious, requiring expensive equipment and long times. A better alternative is to design chemical sensors. In the work reported here, six metalloporphyrins (Cu2+ or Zn2+) with different peripheral groups – benzoate, tosylate and carboxylate
– were studied. The stability constants for these compounds were determined with histamine at different temperatures. Histamine is strongly bound to metallic porphyrins containing Cu2+ and Zn2+; however, the binding force does not depend exclusively on
the metal center. Stabilization of the complex is strongly influenced, in some cases, by the lateral chains of the porphyrin. This possibility implies that this system can be very selective for this biogenic amine.
Document Type: Research Article
Affiliations: 1: Departamentos de Química Inorgánica y Nuclear, Universidad Nacional Autónoma de México, México D.F., México 2: y Farmacia, Universidad Nacional Autónoma de México, México D.F., México 3: Departamentos de Química Inorgánica y Nuclear, Universidad Nacional Autónoma de México, Ciudad Universitaria, México D.F., 04510, México, ; [email protected], Email: [email protected]
Publication date: 01 August 2009
- Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
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