Inhibition of both Trypanosoma brucei bloodstream form and related glycolytic enzymes by a new kolavic acid derivative isolated from Entada abyssinica
A new kolavic acid derivative known from spectroscopic analyses as monomethyl ester-15-kolavic acid was isolated from the stem bark of Entada abyssinica, a plant traditionally used in West and East Africa for the management of sleeping sickness. The new derivative showed a strong
and selective inhibitory activity on the GAPDH enzyme of Trypanosoma brucei with an IC50 value of 0.012 mM.
Document Type: Research Article
Affiliations: 1: Laboratory of Bio-organic and Medicinal Chemistry, Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Yaounde I, Cameroon, Email: [email protected] 2: Laboratory of Bio-organic and Medicinal Chemistry, Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Yaounde I, Cameroon 3: Department of Biology, Higher Teachers Training College, University of Yaounde I, Yaounde I, Cameroon 4: Laboratoire de Synthese et Physicochimie des molecules d'Interet Biologique, Universite Paul Sabatier, Toulouse, France 5: LEDSS, Universite Joseph Fourier, Grenoble, France
Publication date: 01 November 2004
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