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Open Access Relaxant effects of carvacrol on guinea pig tracheal chains and its possible mechanisms

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The bronchodilatory effects of three cumulative volumes (0.02, 0.04, and 0.08 ml) of 1/100 diluted carvacrol were examined by their relaxant effects on tracheal chains of guinea pigs precontracted by 60 mM KCl (group 1) and 10 μM methacholine in two different conditions including: non-incubated tissues (group 2) and incubated tissues with 1 μM propranolol and 1 μM chlorpheniramine (group 3), (for each group, n = 5). The relaxant effects of all three volumes of carvacrol were significantly higher than those of ethanol and even theophylline in all three groups of experiments (p < 0.05 to p < 0.001). There were positive correlations between the relaxant effect of carvacrol and incremental volume (p < 0.05 to p < 0.001). These results indicated that carvacrol has a potent relaxant effect on tracheal chains of guinea pigs which is not due to β2-adrenergic stimulatory, histamine H1, and muscarinic blocking effect.
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Document Type: Research Article

Affiliations: 1: Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad, 91735, Iran, Email: [email protected] 2: Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad, Iran

Publication date: September 1, 2003

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  • Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
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