Modified release bi-layered tablet of melatonin using β-cyclodextrin
A modified release bi-layered tablet of melatonin incorporating a fast release fraction consisting of melatonin-β-cyclodextrin inclusion complex and a slow release fraction containing melatonin in HPMC K15M and Carbopol® 971 P matrices was prepared. The formulation developed showed an initial burst followed by a near zero order release pattern for a period of 8 h. The drug content, physical characteristics and the release profile were unaffected after 3 months of an accelerated stability study at 40 °C and 75% relative humidity.
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Document Type: Research Article
Publication date: September 1, 2003
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