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Open Access Modified release bi-layered tablet of melatonin using β-cyclodextrin

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A modified release bi-layered tablet of melatonin incorporating a fast release fraction consisting of melatonin-β-cyclodextrin inclusion complex and a slow release fraction containing melatonin in HPMC K15M and Carbopol® 971 P matrices was prepared. The formulation developed showed an initial burst followed by a near zero order release pattern for a period of 8 h. The drug content, physical characteristics and the release profile were unaffected after 3 months of an accelerated stability study at 40 °C and 75% relative humidity.
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Document Type: Research Article

Publication date: September 1, 2003

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  • Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
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