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Open Access Simultaneous resolution of a binary mixture of captopril and hydrochlorothiazide in tablets by bivariate and multivariate spectral calibrations

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The multivariate spectral calibration methods, two-linear regression-calibration (bivariate calibration (BC)) and multi-linear regression-calibration (MLRC) are proposed for the simultaneous resolution of a binary mixture of hydrochlorothiazide (HCT) and captopril (CTP), which have closely overlapping spectra. The BC and MLRC calibration algorithms are described for the two-component system, HCT-CTP. Some alternative methods, classical least squares (CLS), inverse least squares (ILS), principal component regression (PCR) and principal least squares (PLS) methods, were also used to determine HCT and CTP in the mixture. Using a synthetic mixture of the two drugs, all the methods were validated and applied to tablets. The BC and MLRC methods which are very rapid, and easy to apply, yet not expensive, are powerful tools with very simple mathematical contents for the quantitative analysis. Data treatment was performed using MAPLE V, EXCEL and SPSS 10.0 Software.
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Document Type: Research Article

Affiliations: 1: Department of Analytical Chemistry, Faculty of Pharmacy, University of Ankara, Tandoğan, Ankara, Turkey 2: Department of Analytical Chemistry, Faculty of Pharmacy, University of Ankara, Tandoğan, Ankara, 06100, Turkey, Email: [email protected]

Publication date: September 1, 2003

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  • Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
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