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Open Access Synthesis and study of pigment aggregation response of some melatonin derivatives

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This study was performed to investigate the reactivity of melatonin towards various chemical reagents to produce new derivatives of melatonin containing extra- or fused heterocyclic systems such as the imidazoindole derivatives 3, 5, 6, the triazinoindole derivatives 8a, b, the thiadiazoloindole derivative 12, the pyridinoindole derivative 16 and the aminopyrazolomelatonin derivatives 21a, b and 22a, b. The structures of the compounds were established based on the analytical and spectral data. Agonist and antagonist potency of some melatonin derivatives in clonal Xenopus laevis melanophore cells was studied in comparison with melatonin.
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Document Type: Research Article

Affiliations: 1: Hormone Department, National Research Centre, Cairo University, Giza, Egypt 2: Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt, Email: [email protected]

Publication date: September 1, 2003

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  • Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
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