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Open Access Constituents of Peucedanum zenkeri seeds and their antimicrobial effects

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The methanol extract of Peucedanum zenkeri L. seeds showed antimicrobial activity which is concentrated in the n-hexane fraction. Bioactivity-guided chromatographic fractionation of the seeds of P. zenkeri led to the isolation and characterization of five major coumarins, umbelliprenin, imperatorin, bergapten, isopimpinellin and byakangelicin, as well as two minor coumarins, 7-methoxy coumarin and 5-hydroxy-8-methoxy psoralen. Amongst the isolated compounds only imperatorin, bergapten and isopimpinellin were found to possess anti-microbial activity.
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Document Type: Research Article

Affiliations: 1: National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi, Mississippi, USA 2: Department of Chemistry, University of Buea, Buea, Cameroon 3: International Centre for Ethnomedicine and Drug Development, Nsukka, Nigeria 4: Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington DC, USA 5: National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi, Mississippi, MS 38677, USA, Email: [email protected] 6: Department of Pharmacognosy, School of Pharmacy, University of Mississippi, Mississippi, USA

Publication date: August 1, 2003

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  • Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
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