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Open Access Interaction of some esters of 2-, 3-, 4-alkoxyphenylcarbamic acids with surface-bound DNA at a dsDNA modified electrode

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An interaction of some derivatives of 2-, 3-, 4-alkoxyphenylcarbamic acids with dsDNA was investigated using the anodic voltammetric signal at a DNA-based electrochemical biosensor. Significant, however, reversible association was found, particularly in weak acidic and neutral solution where the protonated forms of the drug molecules occur which are electrostatically bound to the negatively charged DNA backbone. Total drug liberation from the DNA layer within 1 min. was observed in blank buffer solution without drug molecules.
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Document Type: Research Article

Affiliations: 1: Department of Analytical Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology, Bratislava, Slovakia 2: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Comenius University, Odbojárov 10, Bratislava, 832 32, Slovakia, Email: [email protected]

Publication date: August 1, 2003

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  • Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
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