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Open Access Naringin and naringenin inhibit nitrite-induced methemoglobin formation

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Naringin and naringenin protect hemoglobin from nitrite-induced oxidation to methemoglobin. The protection is not observed when naringin and naringenin are added after the autocatalytic stage of the oxidation of hemoglobin by nitrite. The ability of naringin and naringenin to scavenge oxygen free radicals may be responsible for the action because superoxide, hydroxyl and other free radicals are implicated in promoting the autocatalytic stage of oxidation of hemoglobin by nitrite. Both compounds showed less ability to protect intact erythrocytes suggesting that they may not cross the erythrocyte membrane in sufficient amounts. Naringenin was more effective than naringin, probably because of the extra phenolic group in the aglycone.
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Document Type: Research Article

Affiliations: 1: Department of Pharmacology, College of Pharmaceutical Sciences, Manipal, India 2: Department of Pharmacology, College of Pharmaceutical Sciences, Manipal, 576119, India, Email: [email protected] 3: Department of Pharmaceutical Chemistry, Department of Pharmaceutics, College of Pharmaceutical Sciences, Manipal, India 4: Department of Pharmaceutics, College of Pharmaceutical Sciences, Manipal, India 5: Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Manipal, India, Manipal, India

Publication date: August 1, 2003

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  • Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
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