The purpose of this investigation was to develop a membrane-moderated transdermal therapeutic system (TTS) of nimodipine using 2% w/w hydroxypropylmethylcellulose (HPMC) gel as a reservoir system containing 10% w/w of carvone (penetration enhancer) in 60% v/v ethanol.
The flux of nimodipine through an ethylene vinyl acetate (EVA) copolymer membrane was found to increase with an increase in vinyl acetate content in the copolymer. The effect of a pressure-sensitive adhesive (TACKWHITE A 4MED®) on the permeability of nimodipine through an EVA 2825 membrane
(28% w/w vinyl acetate) or an EVA 2825 membrane/skin composite was also studied. An EVA 2825 membrane coated with TACKWHITE 4A MED® was found to provide the required flux of nimodipine (117 ± 5 μg/cm2/h) across rat abdominal skin. Thus a new transdermal therapeutic
system for nimodipine was formulated using EVA 2825 membrane, coated with a pressure-sensitive adhesive TACKWHITE 4A MED®, and 2% w/w HPMC gel as reservoir containing 10% w/w of carvone as a penetration enhancer. Studies in healthy human volunteers indicated that the TTS
of nimodipine, designed in the present study, provided steady-state plasma concentration of the drug with minimal fluctuations.
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Document Type: Research Article
Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam, 530 003, India, Email: [email protected]
Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam, India
Publication date: August 1, 2003
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