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Open Access Mass spectrometric study of the photooxidation of the ophthalmic drugs timolol and pindolol

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A mass spectrometric study of the photooxidation products of the ophthalmic drugs pindolol (1-[1H-indol-4-yloxyl]-3-[isopropylamino]-2-propa†nol) and timolol (S-[–]-1-[t-butylamino]-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxyl]-2-propanol) in water has been performed by LC-MS. Based on these data and the assumption that photooxidation mainly occurs through singlet molecular oxygen attack, a possible reaction mechanism is proposed. The mechanistic pathways involve singlet oxygen attack to the pindolol indole ring and oxidation of the pindolol isopropyl or timolol terbutyl methyl groups.
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Document Type: Research Article

Affiliations: 1: Departamento de Química, Univ. Nac. de Río Cuarto, Río Cuarto, Argentina 2: Laboratorio LADECOR, División Química Orgánica, Departamento de Química, Fac. de Cs. Exactas, Univ. Nac. de La Plata, Río Cuarto, Argentina 3: Laboratorio LADECOR, División Química Orgánica, Departamento de Química, Fac. de Cs. Exactas, Univ. Nac. de La Plata, Calle 47 y 115, Río Cuarto, 1900, Argentina 4: Centro Médico Privado de la Visión, Río Cuarto, Argentina

Publication date: August 1, 2003

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  • Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
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