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Open Access Synthesis of some new benzothiazole derivatives as potential antimicrobial and antiparasitic agents

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Several thiazolidinonyl benzothiazoles 8ab and thiazolinylbenzothiazoles 9aj were synthesized by the reaction of 2-(N-substituted thiocarbamoyl hydrazino) benzothiazoles 7ad with chloroacetic acid or phenacyl bromide respectively. The intermediate compounds 7ad were prepared in a good yield by the reaction of 2-hydrazinobenzothiazole (6) with phenylisothiocyanates. Synthesis of hydrazones 10ac were performed by the reaction of 6 with the corresponding aldehydes. Trials to cyclize the obtained hydrazones 10ac into the corresponding triazolo derivatives 11ac were unsuccessful. Addition of 4-morphylino carbonyl chloride to compound 6 yielded the corresponding 2-acid hydrazide derivative 12. Some of the prepared compounds were screened for their anti-parasitic activity. Most of them showed reasonable antinematodal or schistosomicidal activity. In addition, antimicrobial screening of all of the prepared new compounds was performed against Staphylococcus aeurus ATCC 6538, Escherichia coli ATCC 8735 and Candida albicans ATCC 10321 but non of them was active.
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Document Type: Research Article

Affiliations: 1: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria, 21521, Egypt 2: Department of Parasitology, Faculty of Medicine, University of Alexandria, Alexandria, Egypt

Publication date: August 1, 2003

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  • Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
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