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Ultrasonic Separation of Suspended Particles - Part III: Application in Biotechnology

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This paper describes a novel acoustic filter for the retention of mammalian cells in cell culture fermentations. The filter is based on a multilayered piezoelectric resonator. It is operated in flow-through mode and utilizes the acoustic forces on the cells in a standing ultrasonic field. The background of animal cell culture fermentation is briefly reviewed. The functional principle, the resonator design, and the implementation of the acoustic filter are discussed. System performance is analyzed by comparison to conventional stirred tank fermentation. Experimental results obtained with two different hybridoma cell lines (human hybridoma with average cell concentration and mouse hybridoma with high concentration) are presented. A significant increase of cell concentrations and product output (daily harvest) could be achieved with this new acoustic filter technique.
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Document Type: Research Article

Publication date: September 1, 1998

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  • Acta Acustica united with Acustica, published together with the European Acoustics Association (EAA), is an international, peer-reviewed journal on acoustics. It publishes original articles on all subjects in the field of acoustics, such as general linear acoustics, nonlinear acoustics, macrosonics, flow acoustics, atmospheric sound, underwater sound, ultrasonics, physical acoustics, structural acoustics, noise control, active control, environmental noise, building acoustics, room acoustics, acoustic materials, acoustic signal processing, computational and numerical acoustics, hearing, audiology and psychoacoustics, speech, musical acoustics, electroacoustics, auditory quality of systems. It reports on original scientific research in acoustics and on engineering applications. The journal considers scientific papers, technical and applied papers, book reviews, short communications, doctoral thesis abstracts, etc. In irregular intervals also special issues and review articles are published.
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