BACKGROUND: Noninvasive monitoring of cryosurgery is important for performing precise monitoring of the freezing process in situ and evaluating postoperative effects after therapy. One potential approach is to monitor the normal and freeze-thawed tissues through ultrasonic backscattered
signal processing. OBJECTIVE: To develop a noninvasive method for cryosurgery monitoring based on the analysis of microstructural characteristics of in vitro porcine liver tissues in different states, including normal and freeze-thawed tissues, by estimating the center frequency of
scatterers (CFS) using the autoregressive (AR) cepstrum of ultrasonic backscattered signals. MATERIALS AND METHODS: The method is based on the discrete scattering model described in the tissue characterization literature and the observation that most biological tissues are semi-regular
scattering lattices. A total of ten in vitro porcine liver samples were used in the experiments. RESULTS: Experimental results show that the CFS in porcine liver tissues decreases after prefreezing and then thawing. CONCLUSION: The CFS obtained using this method may be used as
a characteristic parameter for tissue characterization during the noninvasive monitoring of the transition zone between frozen and unfrozen tissues during surgical therapy, and to evaluate postoperative effects.
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ULTRASOUND TISSUE CHARACTERIZATION
Document Type: Research Article
May 1, 2020
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CryoLetters is a bimonthly international journal for low temperature sciences, including cryobiology, cryopreservation or vitrification of cells and tissues, chemical and physical aspects of freezing and drying, and studies involving ecology of cold environments, and cold adaptation
The journal publishes original research reports, authoritative reviews, technical developments and commissioned book reviews of studies of the effects produced by low temperatures on a wide variety of scientific and technical processes, or those involving low temperature techniques in the investigation of physical, chemical, biological and ecological problems.