BACKGROUND: Cryotherapy and hyperthermia are effective treatments for several diseases, especially for liver cancers. Thermal conductivity is a significant thermal property for the prediction and guidance of surgical procedure. However, the thermal conductivities of organs and
tissues, especially over the temperature range of both cryotherapy and hyperthermia are scarce. OBJECTIVE: To provide comprehensive thermal conductivity of liver for both cryotherapy and hyperthermia. MATERIALS AND METHODS: A hot probe made of stain steel needle and micron-sized
copper wire is used for measurement. To verify data processing, both the least square method and the Monte Carlo inversion method are used to determine the hot probe constants, respectively, with reference materials of water and 29.9% Ca2Cl aqueous solution. Then the thermal conductivities
of Hanks solution and pork liver bathed in Hanks solution are measured. RESULTS: The effective length for two methods is nearly the same, but the heat capacity of probe calibrated by the Monte Carlo inversion is temperature dependent. Fairly comprehensive thermal conductivity of porcine
liver measured with these two methods in the target temperature range is verified to be similar. CONCLUSION: We provide an integrated thermal conductivity of liver for cryotherapy and hyperthermia in two methods, and make more accurate predictions possible for surgery. The least square
method and the Monte Carlo inversion method have their advantages and disadvantages. The least square method is available for measurement of liquids that not prone to convection or solids in a wide temperature range, while the Monte Carlo inversion method is available for accurate and rapid
measurement.
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Keywords:
LEAST SQUARE METHOD;
MONTE CARLO INVERSION METHOD;
PORCINE LIVER;
THERMAL CONDUCTIVITY
Document Type: Research Article
Publication date:
01 November 2016
More about this publication?
CryoLetters is a bimonthly international journal for low temperature sciences, including cryobiology, cryopreservation or vitrification of cells and tissues, chemical and physical aspects of freezing and drying, and studies involving ecology of cold environments, and cold adaptation
The journal publishes original research reports, authoritative reviews, technical developments and commissioned book reviews of studies of the effects produced by low temperatures on a wide variety of scientific and technical processes, or those involving low temperature techniques in the investigation of physical, chemical, biological and ecological problems.