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Free Content Effects of Hypothermia on Ischaemic Depolarisation In Brain: A Comparison of Responses in Rat and Gerbil

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The latency of development of ischaemic depolarization (LID) has been used to compare the relative effects of different levels of hypothermia on ischaemic responses in brains of rat and gerbil, using a model with imposed complete cessation of cerebral blood flow (CBF=0). At temperatures reducing from 37°C to 20°C, the LIDs were consistently shorter in the gerbil than in the rat. For example, at 37°C the LID in the gerbil was 0.71±01.2 min, and in the rat, 1.37±0.02 min respectively (P<0.01), whilst at 20°C, the values were 5.48±0.25 min and 7.30±0.76 min (P<0.01). However, the relative effects of hypothermia on each species were similar (by linear regression with slopes of -0.29 and -0.35 min/°C in the two species). There may be underlying differences in brain biophysics or structure between species, but in spite of this, applied hypothermia still imposes a similar depression on the development of ischaemic damage. Both models may thus be used in studies of brain hypothermia as long as the intrinsic differences are appreciated.

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Keywords: BRAIN ISCHAEMIA; COMPARISON; HYPOTHERMIA; LATENCY OF ISCHAEMIC DEPOLARIZATION; OF RAT AND GERBIL

Document Type: Regular Paper

Publication date: 01 June 2004

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  • CryoLetters is a bimonthly international journal for low temperature sciences, including cryobiology, cryopreservation or vitrification of cells and tissues, chemical and physical aspects of freezing and drying, and studies involving ecology of cold environments, and cold adaptation

    The journal publishes original research reports, authoritative reviews, technical developments and commissioned book reviews of studies of the effects produced by low temperatures on a wide variety of scientific and technical processes, or those involving low temperature techniques in the investigation of physical, chemical, biological and ecological problems.

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