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Free Content Gene expression in response to low temperatures in mammalian cells: a review of current ideas

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This review was undertaken to identify responses of mammalian cells to cold temperatures, such as might be encountered in therapeutic procedures where body temperatures are lowered, in preservation of cells and organs, and in cryopreservation. In general, cold elicits a range of stress responses through identified signaling pathways, which may determine the survival or otherwise of the cells. Under conditions of mild hypothermia, there is evidence for responses which reflect an ordered acclimation to the new environment, whilst deep cooling invokes a more generalised stress response.

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Keywords: CRYOPRESERVATION; GENE PRODUCTS; HYPOTHERMIA; LOW TEMPERATURES; STRESS RESPONSE

Document Type: Research Article

Affiliations: University Department of Surgery, Royal Free & University College Medical School, London NW3 2QG, UK.

Publication date: March 1, 2003

More about this publication?
  • CryoLetters is a bimonthly international journal for low temperature sciences, including cryobiology, cryopreservation or vitrification of cells and tissues, chemical and physical aspects of freezing and drying, and studies involving ecology of cold environments, and cold adaptation

    The journal publishes original research reports, authoritative reviews, technical developments and commissioned book reviews of studies of the effects produced by low temperatures on a wide variety of scientific and technical processes, or those involving low temperature techniques in the investigation of physical, chemical, biological and ecological problems.

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