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Gene Expression Profiles of the Aurora Family Kinases

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The evolutionarily conserved Aurora family kinases, a family of mitotic serine/threonine kinases, has three members in humans (Aurora-A, -B and -C). Overexpression of Aurora family members, particularly Aurora-A, has been reported in many human cancers and cell lines. In this study, we present evidence based on comparative gene expression analysis via quantitative RT-PCR to delineate the relative contributions of these kinases in 60 cell lines and statistical analysis in five different human cancer microarray datasets. The analysis demonstrated the selective upregulation of these Aurora members in various cancers. In general, Aurora-A exhibited the highest expression levels, with substantially decreased quantities of the Aurora-C transcript detected relative to Aurora-A and -B. Moreover, to characterize the roles of each Aurora member, which share many similarities, we investigated the expression profiles of the family in normal tissues and a panel of different phases of the HeLa cell cycle. Finally, both Aurora-A and -B were overexpressed in a majority of esophageal tumor tissues in comparison to the normal variants. Taken together, the results show that each Aurora member exhibits distinct expression patterns, implying that they are engaged in different biological processes to accomplish more elaborate cell physiological functions in higher organisms.
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Keywords: Aurora family; Aurora-A; Aurora-B; Aurora-C; Esophageal carcinoma; Quantitative RT-PCR

Document Type: Review Article

Affiliations: 1: Division of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli County 350, Taiwan, R.O.C., 2: Division of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli County 350, Taiwan, R.O.C., Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan, R.O.C., 3: Institute of Public Health, National Yang-Ming University, Taipei 112, Taiwan, R.O.C., 4: Division of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli County 350, Taiwan, R.O.C. 5: Institute of Biopharmaceutical Science, National Yang-Ming University, Taipei 112, Taiwan, R.O.C. 6: Institute of Biomedical Science, National Sun Yat-Sen University, Kaohsiung 804, Taiwan, R.O.C. 7: Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan, R.O.C. 8: Department of Education and Research, Taichung Veterans General Hospital, Taichung 400, Taiwan, R.O.C. 9: Department of Life Science, Fu-Jen Catholic University, Taipei Hsien 242, Taiwan, R.O.C.

Publication date: January 1, 2006

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  • Gene Expression, The Journal of Liver Research will publish articles in all aspects of hepatology. Hepatology, as a research discipline, has seen unprecedented growth especially in the cellular and molecular mechanisms of hepatic health and disease, which continues to have a major impact on understanding liver development, stem cells, carcinogenesis, tissue engineering, injury, repair, regeneration, immunology, metabolism, fibrosis, and transplantation. Continued research and improved understanding in these areas will have a meaningful impact on liver disease prevention, diagnosis, and treatment. The existing journal Gene Expression has expanded its focus to become Gene Expression, The Journal of Liver Research to meet this growing demand. In its revised and expanded scope, the journal will publish high-impact original articles, reviews, short but complete articles, and special articles (editorials, commentaries, opinions) on all aspects of hepatology, making it a unique and invaluable resource for readers interested in this field. The expanded team, led by an Editor-in-Chief who is uniquely qualified and a renowned expert, along with a dynamic and functional editorial board, is determined to make this a premier journal in the field of hepatology.
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