Effect of acupuncture on the expressions of nitric oxide synthase (NOS) and neuronal NOS (nNOS) in the cerebral cortex of streptozotocin (STZ)-induced diabetic rats was investigated. Animals were divided into four groups; the control group, the nondiabetic and acupunctured group, the
STZ-induced-diabetes group, and the STZ-induced diabetic and acupunctured group. To produce the diabetic animal model, a single intraperitoneal injection of STZ (50 mg/kg) was given to each animal; animals of the nondiabetic groups received equivalent amounts of normal saline, also via intraperitoneal
injection. From the results, acupuncture was shown to increase the numbers of nicotinamide adenine dinucleotide phosphate-diaphorase-positive and nNOS-positive neurons in STZ-induced diabetic rats. From the present study, it may be suggested that acupuncture modulates NOS and nNOS expressions
in the cerebral cortex under diabetic conditions.
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Neuronal nitric oxide synthase;
Nicotinamide adenine dinucleotide phosphate-diaphorase;
Document Type: Research Article
Dept. of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea
Dept. of Sports and Leisure Studies, Hannam University, Daejeon, Korea
Dept. of Meridianology, College of Oriental Medicine, Semyung University, Chungbuk, Korea
Publication date: January 1, 2003