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ROLES OF OPIOID PEPTIDES OF PAG IN ANALOGOUS ELECTRO-ACUPUNCTURE INHIBITION OF EXPERIMENTAL ARRHYTHMIA: ANALYZED BY SPECIFIC ANTISERA MICROINJECTION

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Using specific antisera microinjected into periaqueductal grey (PAG), we further studied the mechanism of the analogous electroacupuncture, deep peroneal nerve stimulation (DPNS), inhibition on the experimental arrhythmia, hypothalamic stimulation-induced ventricular extrasystoles (HVE). Neither normal serum nor anti-leu-enkephalin antiserum interfered with DPNS inhibition; anti-dynorphin A (1-8) tended to attenuate the inhibition; and anti-ß-endorphin antiserum blocked it. The results provided further evidence for the hypothesis that ß-endorphin in PAG plays an important role in the neural circuit of DPNS inhibition on HVE.
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Keywords: arrhythmia; electro-acupuncture; endogenous opioid peptides; hypothalamus; periaqueductal grey; somatic nerve input

Document Type: Research Article

Publication date: January 1, 1986

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