Update on Screening in Prostate Cancer Based on Recent Clinical Trials
Methods for the Review: We reviewed the recent literature using PUBMED research, using as words for research: Prostate- Specific Antigen, mass screening, Prostatic neoplasm mortality, follow-up studies, overdiagnosis and overtreatment. In particular, we analysed two clinical trials reported on “ The New England Journal of Medicine” this year: the European Randomized Study of Screening for Prostate Cancer (ERSPC) by Scroeder et al. and the U.S. Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial by Andriole et al.
Results and Conclusions: The goal of a screening is to detect a cancer at an early stage, when it is still curable. In Pc case there are different treatments with curative intent, that are associated with significant morbidity. Some man have an aggressive form for which screening might be helpful but many have a slow growing cancer that would never progress and their detection could cause anxiety and bring unnecessary medical treatment. With this review we tried to understand where we should stop the management: Overdiagnosis or Overtreatment?
Keywords: DRE; European Randomized Study of Screening for Prostate Cancer; PLCO; PLCO Trial; Prostate neoplasm; Radical prostatectomy, radiotherapy, hormone therapy; digital rectal examination; lower urinary tract symptoms; proliferation inflammatory atrophy; prostate specific antigen; screening
Document Type: Research Article
Publication date: January 1, 2011
- Reviews on Recent Clinical Trials publishes frontier reviews on recent clinical trials of major importance. The journal's aim is to publish the highest quality review articles in the field. Topics covered include: important Phase I - IV clinical trial studies, clinical investigations at all stages of development and therapeutics.
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