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Virulence Factors of Helicobacter pylori: Practical Biomarkers

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Helicobacter pylori are the main cause of gastritis, peptic ulceration and distal gastric adenocarcinoma. Bacterial virulence factors actively contribute in the clinical outcome and progression of Helicobacter pylori infection. The wide range of digestive disease attributed with Helicobacter pylori infection has led scientists to a huge interest in biomarkers. Thus, determination of a biomarker as practical patent for each infectious disease needs a logical clinical set up. Identification of a validated biomarker for Helicobacter pylori calls further investigations including in vitro and in vivo experiments. Undoubtedly, determination of best available biomarker such as dupA can help physicians to go one step further to manage persistent colonizsation of Helicobacter pylori.
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Keywords: Biomarkers; Helicobacter pylori; cagA; clinical outcome; dupA; oipA

Document Type: Research Article

Publication date: May 1, 2014

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  • Recent Patents on Biomarkers publishes review and research articles, and guest edited thematic issues on important recent patents on biomarkers. The coverage includes novel biomarkers in basic, medical, environmental, and pharmaceutical research. A selection of important and recent patents on biomarkers is also included in the journal. The journal is essential reading for all researchers involved in biomarker research and discovery. The journal also covers recent research (where patents have been registered) in fast emerging patent biomarker applications; discovery and validation are covered for drug discovery, clinical development and molecular diagnostics.
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