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Anti-Angiogenesis Activities of Dietary Constituents and Health Foods with Potential Anti-Hepatocellular Carcinoma Activity

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Hepatocellular carcinoma (HCC) is typically a hypervascular tumor with a high mortality rate, and angiogenesis is considered key to its occurrence and progression. Intrinsic angiogenic growth factors, such as vascular endothelial growth factor and fibroblast growth factor are involved in HCC progression, but anti-angiogenesis treatments have so far had only limited clinical efficacy. Recently, coffee intake has been reported to be associated with decreased HCC incidence. Here, we review the anti-angiogenesis activities of dietary constituents and health foods that have been suggested to be effective against HCC in humans, in animal models or in vitro. We also cover recent patents issued for antiangiogenic agents, including dietary constituents and health foods.
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Keywords: Angiogenesis; angiogenic growth factors; anti-angiogenesis treatments; dietary constituents; fibroblast growth factor; health foods; hepatitis B virus; hepatocellular carcinoma; vascular endothelial growth factor

Document Type: Research Article

Publication date: May 1, 2012

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  • Recent Patents on Biomarkers publishes review and research articles, and guest edited thematic issues on important recent patents on biomarkers. The coverage includes novel biomarkers in basic, medical, environmental, and pharmaceutical research. A selection of important and recent patents on biomarkers is also included in the journal. The journal is essential reading for all researchers involved in biomarker research and discovery. The journal also covers recent research (where patents have been registered) in fast emerging patent biomarker applications; discovery and validation are covered for drug discovery, clinical development and molecular diagnostics.
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