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Inflammatory Biomarkers in Chronic Kidney Disease: A Review

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Interest in the association between inflammation and chronic kidney disease (CKD) is increasing. During the last 20 years, classical markers have shown an important association between inflammation and mortality in all stages of CKD. Newly discovered biomarkers can help to predict the course of CKD and identify patients at risk of cardiovascular disease and death. They may also come to play an important role in preventing CKD and it complications. In this review, we summarize the most relevant inflammatory biomarkers and examine their role in diagnosis and prognosis. Also, new relevant patents are described in order to provide an idea for future developments.
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Keywords: C-reactive protein; Cardiovascular events; TWEAK; chronic kidney disease; circulating cytokines; hemodialysis; hemodialysis membranes; inflammatory biomarkers; interleukins; subclinical infections

Document Type: Research Article

Publication date: May 1, 2012

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  • Recent Patents on Biomarkers publishes review and research articles, and guest edited thematic issues on important recent patents on biomarkers. The coverage includes novel biomarkers in basic, medical, environmental, and pharmaceutical research. A selection of important and recent patents on biomarkers is also included in the journal. The journal is essential reading for all researchers involved in biomarker research and discovery. The journal also covers recent research (where patents have been registered) in fast emerging patent biomarker applications; discovery and validation are covered for drug discovery, clinical development and molecular diagnostics.
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