Transcriptomics in Cancer - Stages Toward Patents in Biomarkers?
Transcriptomics in cancer is one of the newly researched domains because it mirrors all the post genomic variation. In spite of extended studies, carcinogenesis still remains a highly unknown process due to multiple factors that are involved in cancer initiation. Carcinogenesis is a complex network of processes starting from genetic alterations, accumulation of mutation, going through epigenetic alteration and ending with proteomic alterations that can lead to uncontrolled proliferation, differentiation, invasion, and ultimately metastasis. From gene to protein, cancer cells can be studied at transcriptomic level in order to detect new relevant biomarkers and/or new drug targets. We highlight herein some of the cancers that were lately subjects for transcriptomic biomarkers patents, among which: breast, prostate, oral, brain, pancreatic cancer and cutaneous melanoma. A glimpse of the up-dated methodology and analysis used in transcriptomics is presented along with the recent patents that claim transcriptomics biomarkers.
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Document Type: Research Article
Publication date: May 1, 2012
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- Recent Patents on Biomarkers publishes review and research articles, and guest edited thematic issues on important recent patents on biomarkers. The coverage includes novel biomarkers in basic, medical, environmental, and pharmaceutical research. A selection of important and recent patents on biomarkers is also included in the journal. The journal is essential reading for all researchers involved in biomarker research and discovery. The journal also covers recent research (where patents have been registered) in fast emerging patent biomarker applications; discovery and validation are covered for drug discovery, clinical development and molecular diagnostics.
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