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Recent Patents in Glycan-Based Cancer Biomarkers and Discovery Technologies

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Glycosylation is one of the most common post-translational modifications on proteins and lipids. The functions of glycosylation include immune regulation and pathogen invasion, signaling, protein structure regulation, protein quality control and degradation, and cell adhesion and migration. Due to these diverse functions, detecting glycosylation has recently become a target of biomedical research. Many recent advances have been made in glycosylation analysis. Microarray and mass spectrometry improvements have made whole glycoproteome analysis possible and the identification of abnormal glycosylation patterns associated with various diseases. Cancer associated glycan structures, glycosylation changes, and glycoforms of proteins are becoming increasingly used for biomarker development and treatment options. This article discusses recent patents involving technology and methodology advances in glycosylation analysis along with cancer-specific glycosylation-based biomarkers. Owing to the recent development of the field, pending patents detailing glycosylation analysis methods and glycan-based biomarkers are included in this review.

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Keywords: Affinity-based methods; Biomarkers; Cancer-associated glycoforms; Mass Spectrometry based methods; anti-glycan antibodies; cancer detection; cancer diagnosis; glycomics technology; glycoproteomics; glycosylation; patent

Document Type: Research Article

Publication date: September 1, 2011

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  • Recent Patents on Biomarkers publishes review and research articles, and guest edited thematic issues on important recent patents on biomarkers. The coverage includes novel biomarkers in basic, medical, environmental, and pharmaceutical research. A selection of important and recent patents on biomarkers is also included in the journal. The journal is essential reading for all researchers involved in biomarker research and discovery. The journal also covers recent research (where patents have been registered) in fast emerging patent biomarker applications; discovery and validation are covered for drug discovery, clinical development and molecular diagnostics.
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